Nah. Just remeber main notes on your fretboard: A,B,C,D,E,F,G that’s actually all you need actually. From what I know it’s ebough to play any piece of music you want (since you know that flat is just one fret left and sharp is one fret right).
I play usual tuning guitar, C-tuning guitar, and sometimes use “open-G” tuning. When playing in speed I often don’t actually know what notes I’m playing since all that tunings are mixed up in my head. But because a lot of practice my fingers know where to land. So once I have at least one reference note (open E for example) it’s not a problem to play any music from a sheet.
It’s not like you see C# in your sheet and then press C# on a guitar because you know your fretboard. It would be too long. It’s more like you see that it’s a typical descending 6-notes minor run down to a root note, and because you practiced scales enough your finger automatically choose what you need. Same for arpeggios and other different passages.