If you mean the “just feels right” approach, when I put that into my practice and really focused on it, it has worked for me, and produced something more in the way of a cross-picking movement than anything else. But I would find it difficult to stay on that bicycle for more than a week or so. Stiffness creeping in, or old habits reasserting themselves. Generally I would try flipping my usual patterns around, try starting on upstrokes where I habitually used downstrokes, that kind of thing, just to shake things up, break some ice jams… for a while. Because without really understanding the mechanics of why it was working, I couldn’t figure out what to do when it stopped working. So the CTC thing has been hugely useful in that respect for practicing. Getting those big, wide-open sounding pentatonic blues things going has always been a big challenge for me, sometimes I can do it, sometimes it goes away, so thinking about it in this more granular way–like, just having a logic for when you want to sweep vs alternate, not that it’s an absolute rule but knowing that’s going to be more efficient (read “EASIER”!) for certain things, is huge.
There’s a learning styles thing, too. I think some players have a gift for imitation–for really fitting their ear and mechanics to reproduce not just the notes but the “feel” of other players, without necessarily involving the cerebral cortex so much. Sit down with a record, go over that guy’s lick until you really get inside how he’s playing it, why the same notes sound better if you do it this way instead of that. One way that works is that those licks act like anchors (in a good way), reminding your brain of that this feels right feeling, so you can return to them as a way of keeping you in that groove while you’re moving around in a solo. I think SRV has that kind of thing going. I think the players for whom it works are some of the best in the world.
I think that’s also a very powerful way to learn, and sometimes, again, it has worked for me, but then I want to add something out of my own head that maybe doesn’t fit so well and… then it’s really great to have a logic for analyzing what’s wrong rather than just If I just do this a lot more and more and more it will get easier. But I also highly prize the ability to come up with crazy shit on the fly in performance. Like @Acecrusher-- “Learn it all, then forget it,” is a great way to put it. Or as a guitar teacher once put it to me when laying out some complicated etude for me to try and master, “You gotta go to prison in order to get free.”