I tune in 4ths and like it, as Eb Ab Db Gb B E. The upside is that one doesn’t have to adjust fingering when crossing between the G and B strings in a standard tuning, so there is just a lot less to memorize, and a lot more regularity to the neck. It’s easier to find notes as they have a really obvious pattern.
The downside is that (a) one can’t directly read regular TAB, (b) some popular chords—particularly those that span all six strings—cannot be fingered, and (c) one might have open strings that no longer make sense for one’s music, hence it might be harder to play certain pieces.
For (a), it’s trivial to adjust, so this isn’t a problem. For (b), I avoid the problem entirely: I play with enough distortion that having more than 4 strings in a chord doesn’t make sense, hence I never have a problem. But note, for example, that I can’t even play a grand barre chord! But, then again, why would I want to play one, given that it is really just {1, 5, 1, 3, 5, 1}—do I really need so many roots? No, I’d just do something like {1, 3, 5}, etc., as I have so much signal processing.
You might be interested in somebody like Tom Quale, I believe he has extensive material on why he likes 4ths, and he, I believe, likes complex chords.