I recently upgraded my computer and had similar issues (upgraded to a i7 12700, 64 gb ddr4). On my old computer I could easily set the buffer size to 128 without issues but on my new computer there was a lot of clicks and noise… I found this link and it helped med fix the issue. Especially:
Ensure your interface has its own dedicated USB port
USB hubs are known to cause issues with audio devices. These issues can include noise, disconnections and even the interface not being detected at all. Therefore, it is recommended that your interface is connected directly to its own USB port. (I put it in a USB 3.2 port)
Disable USB selective suspend
This feature can cause problems with devices connected via USB.
- Search for ‘Edit power plan’
- Click ‘Change advanced power settings’
- Click ‘USB settings’
- Click ‘USB Selective suspend setting’
- Click ‘disable’
I also changed my computers power plan to “High performance”.
I don’t know if this will fix your problem but it did fix mine so I thought I’d share it.
Now I set my buffer size to 64 @ 48 kbit and I don’t get any crackling sound anymore (not even when using multiple instruments in my DAW).