I have tried many different string gauges and tunings. I think the Eb tuning is more pleasing to the ear AND the hands, especially with 9s. I used to play like that for years.
I then switched to Eb with 10s, because I wanted the bottom strings to be tighter when in Drop-D. It was still doable compared to the 9s.
Then I switched to E-tuning (because I collaborate with people that use standard tuning) and I kept the 10s. Besides the guitar sounding brighter (matter of taste if you like that), the strings are much tighter and the 10s in standard mess up my bends and vibrato, because I need much more strength to bend up and do vibrato. Also, I like doing vibrato on the lower strings as well, which is sort of impossible with 10s. Speed suffers as well, because of more strength required to press down. The plus side is that you can really hit hard without detuning or breaking the strings.
Because I will stay with E-tuning (until I have more guitars) I will probably switch to using 9s again or a 9/10 hybrid set. Probably the hybrid set is the best compromise between playability and tone.
(By the way, once I tried 11s in Eb. The sound changed to more bass and volume, which I didn’t like, and to compensate for that, you might as well keep playing with 10s, which are far easier to play.)