Hi @WhammyStarScream. Sorry for the late reply, I hadn’t seen this post.
I’ve used this product before, it’s essentially a moisturizer for dry hands.
I am a university lecturer, and part of my job is writing mathematics on blackboards with chalk. I don’t usually have a problem with dry hands, but when I was working in Beijing, the combination of the dry climate and the poor quality of the chalk I was supplied with quickly resulted in very dry, cracking skin. I sourced my own chalk and some different hand creams, including O’Keeffe’s. I found O’Keeffe’s was the most effective hand cream for me.
I was also recommended this product later when I started indoor climbing. The climbing chalk and the friction on the hand holds also results in dry hands and skin that can crack (or tear off on the holds, look up “climbing flapper”). While I was climbing (I had to stop due to the pandemic), I started taping my fingers to give a layer of protection between my skin and the holds, and using O’Keeffe’s hand cream after washing the climbing chalk of my hands.
I’m also aware that people who handle cash or other paper often develop dry and cracked skin on their hands. I know that O’Keeffe’s is often recommended and used by bank tellers, people working in print shops, etc.
Essentially any moisturizer works, in part by absorption through the skin. I don’t know if O’Keeffe’s has different absorption properties from other hand creams, that would somehow make it more likely to allow other products mixed with it to permeate the skin. I would be doubtful that O’Keeffe’s carries a risk that is unusual compared to other moisturizers.
It would seem to me that the logical thing to do if you’re worried about other products mixed with moisturizers permeating the skin would be not to mix any other products with moisturizers. I can say that with sparing use, I’ve never had any problems from using O’Keeffe’s.