The only reason for the volume being in the way of the hand is volume swelling, Otherwise it is utterly pointless and in the way of freedom of escape. There is no reason to have the volume knob where it is unless you want to do constant volume control. And that is a very small and advanced aspect of playing that should not be forced on players. A foot pedal is more than enough to do this rather than upsetting most of your technique.
Beating a dead horse fellas, lots of options or learn to live with it. One could complain about a pickup selector position as well in that case, and so on. Stop whining and practice more 
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Donāt you think the adaptation of tools to our body is just as important if not more than us adapting to them?
Saying just get over it ignores the fact you can just go through it, in terms of guitar, an item you have for a long time, why not go through it, make it as economical as you can while keeping it a guitar.
Going over it or dealing it would make sense if itās a short term thing. living with a stone in your shoe is just stupid. Take it off and remove it.
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For me it is not an issue, but I sort of fan my fingers out so they are over the volume knob and donāt hold them closed like I see some do. I donāt even think I could pick with my fingers closed, as it seems like an awkward position to me. But whatever gets the job done for ya, and if you must move the knob.
Happy pickin!
Hehhe, man unless this is some sort of therapy, itās a strat. The way I see it is you have three options:
- Take it up with fender
- Adapt
- Try another strat type guitar
The fourth option is this thread I suppose 
This is a really deep question. In 2019, I decided to use only one pick. I chose a 2.0mm Dunlop Flow in Ultex because it looked good on paper. It was completely strange/annoying/thick/stiff/chirpyā¦ but I decided to just stick to it, no matter what, as if was the worldās only type of pick. Today, I canāt imagine anything else. But it didnāt bend to me: I bent to it. I assume that somebody can pick their primary guitar (Strat, Tele, Les Paul, RG, V, Explorer, St. Vincent, whatever), and then bend to it. The āsmash hand into knob problemā has been resolved by all long-term Strat players, where it can be done, and itās worth the effort if thatās the primary guitar. How does one choose their primary guitar? Well, I suppose it has to look coolā¦ but beyond that, is there a right answer? Iām not sure!
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I know that I would love to feel comfortable on pointy guitars, because I love how pointy guitars look, but my body just cannot feel comfortable on anything other than a strat shape. I borrowed an Ibanez Destroyer for a little bit that I wound up adapting to, but really the strat shape just āfitsā for me.
The idea that you canāt mod a guitar is silly. Imagine if someone told EVH āstrats donāt have humbuckers, deal with it.ā
@WhammyStarScream Iāve seen players ditch the tone control, move the volume where the tone is supposed to go, and plug up the hole left behind by the volume knob. Maybe an option?
Well put. This primary guitar thing I thing is important, I will break myself to adjust to it. This can take a while, question is how badly do you want it !?
Talking about picks, I hope you get to try a blue chip TD 40 or 45, I have one each, and havenāt lost them for a few years now, theyāre all I play with these days, 100% worth it fo me, They last long, no sign of wear in two years with hard playing, stiff, they grip nice when warm, no chirp, and itās like you added a couple of grand in pro gear to your rig, the bass tightens up and good things happen to the mids and top too, I have no idea how this sorcery works but itās awesome.
edit: back to the main topic, it is about commitment to solve the problem if thatās the fight you have chosen to win. And believe me this vol knob thing just disappears after you tackle it once and for all.
edit2:
Iāve been playing SRV style things lately and itās a very different right hand thing than say Malmsteen. Stevie likes to pick over his neck pickup or close to it, while mamlsrteen in away back with the hand anchored on the bridge. The anchored position needs the pinky to be curled around the vol most of the time, there are exceptions. But the SRV stuff is all far away from the vol knob.
The other thing I noticed is Iām almost always anchoring but there are two types:
- edge of palm on the bridge
- pinky and ring finger on the pick guard or body
These two are totally different actions.
So the problem could be that your actor point itās if on the bridge just needs to move back a bit, and then you pinky could just curl the knob while staying āanchoredā?
And if you need to move up for tonal reasons, you lift your palm and anchor primarily on the pinky/ring combo?
Does this make sense to anybody else?