Filter out the low-end of your tone to about 100hz (depending on tuning… use your ears) for rhythms and even higher up for leads. Use the “Andy Sneap” multiband compression trick on the low mids to clamp down on excess buildup. Reaper comes stock with a multiband compressor perfect for this trick, message me when you get there and I’ll walk you through it. Use an Overdrive pedal somewhere in the chain to tighten up the low end response. I like my lead guitars to be more mid-focused so the notes pop out.
In my experience, you generally need less low end in your full-mix guitars than you expect
EDIT: I would also recommend against BIAS. I’ve tried it a few times and I think it’s low-quality for the money you pay. If you’ve got a spare hundo to spend I would just go right to one of the Neural DSP suites. Fortin Namless, NTS, Plini, whichever suites your style the most. I also like Mercuriall stuff a lot but I’m not sure if they do standalone software. Fantastic sounds though.