I like my 1960s 22.5" “student scale” guitars for their smaller overall size. It’s not a fretboard reach issue— it’s just the overall size of the instrument in every dimension. A standard-sized Strat feels like a boat on me. To keep the tension in a playable range, I run 11s on these guitars. But it’s not a perfect solution.
The low strings are still a little floppy, and increasing the gauge doesn’t quite solve the problem. I used to run 12s, but the string thickness was so fat on the wound strings at that point that you’d get buzzing when fretting notes even with good action and good technique.
There simply comes a point where the scale length is too short for the pitch you’re trying to hit, and you can’t fix it by increasing the gauge. For example we have a five-string electric mandolin with a low C string that is essentially unplayable — it’s too floppy, barely holds a consistent pitch when fretted, and goes out of tune at the slightest provocation. If you really need such a wide spread of frequencies on a single instrument, multi-scale is clearly the way to go.
Second issue: There is a sonic change when you have a mismatch between scale length, string gauge, and tuning. A Fender Strat tuned to E at 25.5" is going to have that chimey sound that you simply can’t get on a Mustang tuned to E, even with beefier strings. Some of this is a matter of personal preference. I don’t mind the darker sound of shorter-scale guitars tuned to E. I’m just mentioning this to acknowledge that there are changes due to physics that you can’t dial out by string choice alone.
So… here’s my question for the more mathematically inclined:
With a 22.5" scale length, what string gauge would I need to run, and to what pitch would I need to tune, to get Strat-like string tension, playability, and chime?
That’s an experiment I’d like to try, just to see what it’s like.