Thumb alignment with wrist does it matter?

I’ve noticed that my thumb is more on an angle(kinda like 45ish)a lot of the time compared to being more neutral with the wrist joint which I think happens from switching back and forth between fingerpicking and using a pick. When I play around with this without a pick the more of an angle I have It seem to pull slightly on the wrist so I’m wondering whether this is why I’m finding some of the motions a bit awkward on the wrist.