My guitars are mostly from Warmoth, with scalloped necks and EMG pickups, and my favorites have a Flying-V body (very ergonomic to sit down with). I tune in 4ths, EADGCF, except one semitone flat, and use 8–38 strings. My “amp” is an Axe-FX 2 (XL), it is usually pretending to be a Mesa-Booglie Dual Rectifier. I just run this into a mixer and then a pair of loud powered speakers.
The only thing that I might do is create a balanced set of strings with more even tension, the default 8–38 set is actually pretty terrible in terms of uneven tensions.