This is something also that hits close to home for me. Although I’m not using the more expensive stuff you guys are referring to and I’m just using my iPad.
I just discovered Bias Fx 2 and was pretty impressed with the sounds you can get. Just using the 15 day free trial. I’m sure it’s not as good as helix/neural/ax fx but it really seemed like a game changer as far as relying on one amp/pedals to get multiple sounds.
I went as far as buying one of those inexpensive headrush frfr speakers. The 108 and I’m pretty impressed. Had to do some finagling in the dark to try and produce any actual sound but I figured it out eventually. Configuring iOS for mono and what not. I have stereo cables on the way.
Curious if anyone else uses that setup(w/iPad) as a live setup and how it works.